According to a recent industry trend report, out of more than 6.5 billion messages sent in Q2 of 2009, the average open rate was 22.2%. Their calculation is based on total delivered as: Opened / (Total Sent - Bounces).
Open rates are affected the greatest by the quality of your list and the relevance of your content. If you would like to increase your open rate work on improving both your list quality and your content.
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